The human liver filters about three pints of blood every minute. We know that blood carries the body’s arsenal, immune cells (white blood cells), that help us fight disease. However, we don’t know much about what happens at a molecular level when immune cells leave the blood and trickle through the liver’s narrow corridors.
Which immune cells leave the blood and spend time amongst liver cells?
How long do they spend there and what happens to them next?
How does their passage through the liver microenvironment affect their biology?
To address these questions, we use simple and sophisticated systems, ranging from static co-cultures of blood cells with liver cells to mini liver organ cultures developed in our lab.