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Links to papers from PubMed

Sudden onset hepatitis in children. Kelly DA, Stamataki Z. Nat Rev Gastroenterol Hepatol. 2022 Jul 1:1-2. doi: 10.1038/s41575-022-00652-4. 

Increased Seroprevalence and Improved Antibody Responses Following Third Primary SARS-CoV-2 Immunisation: An Update From the COV-AD Study. Shields AM, Faustini SE, Hill HJ, Al-Taei S, Tanner C, Ashford F, Workman S, Moreira F, Verma N, Wagg H, Heritage G, Campton N, Stamataki Z, Drayson MT, Klenerman P, Thaventhiran JED, Elkhalifa S, Goddard S, Johnston S, Huissoon A, Bethune C, Elcombe S, Lowe DM, Patel SY, Savic S, Richter AG, Burns SO; COV-AD consortium.Front Immunol. 2022 Jun 2;13:912571. doi: 10.3389/fimmu.2022.912571. 

Preferential uptake of SARS-CoV-2 by pericytes potentiates vascular damage and permeability in an organoid model of the microvasculature. Khan AO, Reyat JS, Hill H, Bourne JH, Colicchia M, Newby ML, Allen JD, Crispin M, Youd E, Murray PG, Taylor G, Stamataki Z, Richter AG, Cunningham AF, Pugh M, Rayes J.Cardiovasc Res. 2022 Jun 16:cvac097. doi: 10.1093/cvr/cvac097.

SARS-CoV-2 Vaccine Responses in Individuals with Antibody Deficiency: Findings from the COV-AD Study. Shields AM, Faustini SE, Hill HJ, Al-Taei S, Tanner C, Ashford F, Workman S, Moreira F, Verma N, Wagg H, Heritage G, Campton N, Stamataki Z, Klenerman P, Thaventhiran JED, Goddard S, Johnston S, Huissoon A, Bethune C, Elcombe S, Lowe DM, Patel SY, Savic S, Burns SO, Richter AG; COV-AD consortium.J Clin Immunol. 2022 Apr 14:1-12. doi: 10.1007/s10875-022-01231-7. 

Efficacy of antimicrobial and anti-viral coated air filters to prevent the spread of airborne pathogens. Watson R, Oldfield M, Bryant JA, Riordan L, Hill HJ, Watts JA, Alexander MR, Cox MJ, Stamataki Z, Scurr DJ, de Cogan F.Sci Rep. 2022 Mar 9;12(1):2803. doi: 10.1038/s41598-022-06579-9.

A Role for B Cells to Transmit Hepatitis C Virus Infection. Desombere I, Van Houtte F, Farhoudi A, Verhoye L, Buysschaert C, Gijbels Y, Couvent S, Swinnen W, Van Vlierberghe H, Elewaut A, Magri A, Stamataki Z, Meuleman P, McKeating JA, Leroux-Roels G.Front Immunol. 2021 Dec 16;12:775098. doi: 10.3389/fimmu.2021.775098.

The Role of B Cells in Adult and Paediatric Liver Injury. Patel AM, Liu YS, Davies SP, Brown RM, Kelly DA, Scheel-Toellner D, Reynolds GM, Stamataki Z. Front Immunol. 2021 Sep 23;12:729143. doi: 10.3389/fimmu.2021.729143.

The human liver microenvironment shapes the homing and function of CD4+ T-cell populations. Wiggins BG, Pallett LJ, Li X, Davies SP, Amin OE, Gill US, Kucykowicz S, Patel AM, Aliazis K, Liu YS, Reynolds GM, Davidson BR, Gander A, Luong TV, Hirschfield GM, Kennedy PTF, Huang Y, Maini MK, Stamataki Z. Gut. 2021 Sep 21:gutjnl-2020-323771. doi: 10.1136/gutjnl-2020-323771. 

The Hyperlipidaemic Drug Fenofibrate Significantly Reduces Infection by SARS-CoV-2 in Cell Culture Models. Davies SP, Mycroft-West CJ, Pagani I, Hill HJ, Chen YH, Karlsson R, Bagdonaite I, Guimond SE, Stamataki Z, De Lima MA, Turnbull JE, Yang Z, Vicenzi E, Skidmore MA, Khanim FL, Richardson A.Front Pharmacol. 2021 Aug 6;12:660490. doi: 10.3389/fphar.2021.660490.

Understanding COVID-19: are children the key? Warner S, Richter A, Stamataki Z, Kelly D.BMJ Paediatr Open. 2021 May 19;5(1):e001063. doi: 10.1136/bmjpo-2021-001063.

Formulation of a Composite Nasal Spray Enabling Enhanced Surface Coverage and Prophylaxis of SARS-COV-2. Moakes RJA, Davies  SP,  Stamataki Z and Grover LM. Advanced Materials 31 May 2021 doi: 10.1002/adma.202008304

COVID-19 and liver disease: mechanistic and clinical perspectives.  Marjot T, Webb GJ, Barritt AS 4th, Moon AM, Stamataki Z, Wong VW, Barnes E. Nat Rev Gastroenterol Hepatol. 2021 Mar 10:1-17. doi: 10.1038/s41575-021-00426-4.

Resolution of Persistent COVID-19 After Convalescent Plasma in a Patient with B Cell Aplasia. McKemey E, Shields AM, Faustini SE, Hill HJ, Barnskaya A, Stamataki Z, Gompertz S, Richter AG, Dosanjh D, Madathil S.J Clin Immunol. 2021 Feb 20:1-4. doi: 10.1007/s10875-021-00996-7.

Ex vivo modelling of PD-1/PD-L1 immune checkpoint blockade under acute, chronic, and exhaustion-like conditions of T-cell stimulation. Roberts A, Bentley L, Tang T, Stewart F, Pallini C, Juvvanapudi J, Wallace GR, Cooper AJ, Scott A, Thickett D, Lugg ST, Bancroft H, Hemming B, Ferris C, Langman G, Robinson A, Chapman J, Naidu B, Pinkney T, Taylor GS, Brock K, Stamataki Z, Brady CA, Curnow SJ, Gordon J, Qureshi O, Barnes NM.Sci Rep. 2021 Feb 17;11(1):4030. doi: 10.1038/s41598-021-83612-3.

Structure of human endo-α-1,2-mannosidase (MANEA), an antiviral host-glycosylation target. Sobala ŁF, Fernandes PZ, Hakki Z, Thompson AJ, Howe JD, Hill M, Zitzmann N, Davies S, Stamataki Z, Butters TD, Alonzi DS, Williams SJ, Davies GJ.Proc Natl Acad Sci U S A. 2020 Nov 5:202013620. doi: 10.1073/pnas.2013620117. 

Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science. Evans PC, Ed Rainger G, Mason JC, Guzik TJ, Osto E, Stamataki Z, Neil D, Hoefer IE, Fragiadaki M, Waltenberger J, Weber C, Bochaton-Piallat ML, Bäck M. Cardiovasc Res. 2020 Aug 4:cvaa230. doi: 10.1093/cvr/cvaa230.

Cell-in-Cell Structures in the Liver: A Tale of Four E’s. Davies SP, Terry LV, Wilkinson AL, Stamataki Z. Front Immunol. 2020 May.

The Liver as an Immunological Barrier Redefined by Single Cell Analysis. Stamataki Z, Swadling L. Immunology. 2020 Mar 16. doi: 10.1111/imm.13193.

Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics. Ast J, Arvaniti A, Fine NHF, Nasteska D, Ashford FB, Stamataki Z, Koszegi Z, Bacon A, Jones BJ, Lucey MA, Sasaki S, Brierley DI, Hastoy B, Tomas A, D’Agostino G, Reimann F, Lynn FC, Reissaus CA, Linnemann AK, D’Este E, Calebiro D, Trapp S, Johnsson K, Podewin T, Broichhagen J, Hodson DJ. Nat Commun. 2020 Jan 24;11(1):467. doi: 10.1038/s41467-020-14309-w.

Hepatocytes Delete Regulatory T Cells by Enclysis, a CD4+ T Cell Engulfment Process. Davies SP, Reynolds GM, Wilkinson AL, Li X, Rose R, Leekha M, Liu YS, Gandhi R, Buckroyd E, Grove J, Barnes NM, May RC, Hubscher SG, Adams DH, Huang Y, Qureshi O, Stamataki Z. Cell Rep. 2019 Nov 5;29(6):1610-1620.e4. doi: 10.1016/j.celrep.2019.09.068.

A novel T-cell epitope in the transmembrane region of the hepatitis B virus envelope protein responds upon dendritic cell expansion. Chen L, Zhang Y, Zhang S, Chen Y, Shu X, Lai J, Cao H, Lian Y, Stamataki Z, Huang Y. Arch Virol. 2019 Feb;164(2):483-495. doi: 10.1007/s00705-018-4095-0. Epub 2018 Nov 10.

Clearance of Apoptotic Cells by Tissue Epithelia: A Putative Role for Hepatocytes in Liver Efferocytosis. Davies SP, Reynolds GM, Stamataki Z. Front Immunol. 2018 Jan 25;9:44. doi: 10.3389/fimmu.2018.00044. eCollection 2018.

A Practical Model Evaluating Antiviral Cytokines by Natural Killer Cells in Treatment Naïve Patients with Chronic Hepatitis B Virus Infection. Li X, Gu Y, Guo X, Gu L, Zhou L, Wu X, Wang X, Stamataki Z, Huang Y. Sci Rep. 2017 Jul 19;7(1):5866. doi: 10.1038/s41598-017-06192-1.

MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure. Triantafyllou E, Pop OT, Possamai LA, Wilhelm A, Liaskou E, Singanayagam A, Bernsmeier C, Khamri W, Petts G, Dargue R, Davies SP, Tickle J, Yuksel M, Patel VC, Abeles RD, Stamataki Z, Curbishley SM, Ma Y, Wilson ID, Coen M, Woollard KJ, Quaglia A, Wendon J, Thursz MR, Adams DH, Weston CJ, Antoniades CG. Gut. 2017 Apr 27. pii: gutjnl-2016-313615. doi: 10.1136/gutjnl-2016-313615.

In Vitro and Ex Vivo Models to Study T Cell Migration Through the Human Liver Parenchyma. Wiggins BG, Aliazis K, Davies SP, Hirschfield G, Lalor PF, Reynolds G, Stamataki Z. Methods Mol Biol. 2017;1591:195-214. doi: 10.1007/978-1-4939-6931-9_14.

Using Ex Vivo Liver Organ Cultures to Measure Lymphocyte Trafficking. Wiggins BG, Stamataki Z, Lalor PF. Methods Mol Biol. 2017;1591:177-194. doi: 10.1007/978-1-4939-6931-9_13.

Phenotyping and auto-antibody production by liver-infiltrating B cells in primary sclerosing cholangitis and primary biliary cholangitis. Chung BK, Guevel BT, Reynolds GM, Gupta Udatha DB, Henriksen EK, Stamataki Z, Hirschfield GM, Karlsen TH, Liaskou E. J Autoimmun. 2016 Oct 24. pii: S0896-8411(16)30226-8.

HBV core promoter mutations and AKT upregulate S-phase kinase-associated protein 2 to promote postoperative hepatocellular carcinoma progression. Chen L, Gu L, Gu Y, Wang H, Deng M, Stamataki Z, Oo YH, Huang Y. Sci Rep. 2016 Oct 25;6:35917.

CMV infection of human sinusoidal endothelium regulates hepatic T cell recruitment and activation. Bruns T, Zimmermann HW, Pachnio A, Li KK, Trivedi PJ, Reynolds G, Hubscher S, Stamataki Z, Badenhorst PW, Weston CJ, Moss PA, Adams DH. J Hepatol. 2015 63(1):38-49.

Production, purification and characterization of recombinant, full-length human claudin-1.Bonander N, Jamshad M, Oberthür D, Clare M, Barwell J, Hu K, Farquhar MJ, Stamataki Z, Harris HJ, Dierks K, Dafforn TR, Betzel C, McKeating JA, Bill RM. PloS one 2013 8:e64517

In vitro systems for the study of hepatitis C virus infection. Wilson GK, Stamataki Z. International journal of hepatology 2012 2012: 292591

Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics. Liaskou E, Zimmermann HW, Li KK, Oo YH, Suresh S, Stamataki Z, Qureshi O, Lalor PF, Shaw J, Syn WK, Curbishley SM, Adams DH. Hepatology (Baltimore, Md.) 2013 57: 385-98

Recruitment mechanisms of primary and malignant B cells to the human liver. Shetty S, Bruns T, Weston CJ, Stamataki Z, Oo YH, Long HM, Reynolds GM, Pratt G, Moss P, Jalkanen S, Hubscher SG, Lalor PF, Adams DH. Hepatology (Baltimore, Md.) 2012 56:1521-31

A dual role for hypoxia inducible factor-1α in the hepatitis C virus lifecycle and hepatoma migration. Wilson GK, Brimacombe CL, Rowe IA, Reynolds GM, Fletcher NF, Stamataki Z, Bhogal RH, Simões ML, Ashcroft M, Afford SC, Mitry RR, Dhawan A, Mee CJ, Hübscher SG, Balfe P, McKeating JA. Journal of hepatology 2012 56: 803-9

Hepatitis C virus infects the endothelial cells of the blood-brain barrier. Fletcher NF, Wilson GK, Murray J, Hu K, Lewis A, Reynolds GM, Stamataki Z, Meredith LW, Rowe IA, Luo G, Lopez-Ramirez MA, Baumert TF, Weksler B, Couraud PO, Kim KS, Romero IA, Jopling C, Morgello S, Balfe P, McKeating JA. Gastroenterology 2012 142: 634-643.e6

Immunization of human volunteers with hepatitis C virus envelope glycoproteins elicits antibodies that cross-neutralize heterologous virus strains. Stamataki Z, Coates S, Abrignani S, Houghton M, McKeating JA. The Journal of infectious diseases 2011 204:811-3

Hepatitis C virus targets the T cell secretory machinery as a mechanism of immune evasion. Petrovic D, Stamataki Z, Dempsey E, Golden-Mason L, Freeley M, Doherty D, Prichard D, Keogh C, Conroy J, Mitchell S, Volkov Y, McKeating JA, O’Farrelly C, Kelleher D, Long A. Hepatology (Baltimore, Md.) 2011 53: 1846-53

Structural characterization of CD81-Claudin-1 hepatitis C virus receptor complexes.Bonander N, Jamshad M, Hu K, Farquhar MJ, Stamataki Z, Balfe P, McKeating JA, Bill RM. Biochemical Society transactions 2011 39: 537-40

Common lymphatic endothelial and vascular endothelial receptor-1 mediates the transmigration of regulatory T cells across human hepatic sinusoidal endothelium. Shetty S, Weston CJ, Oo YH, Westerlund N, Stamataki Z, Youster J, Hubscher SG, Salmi M, Jalkanen S, Lalor PF, Adams DH. Journal of immunology (Baltimore, Md. : 1950) 2011 186: 4147-55

Hepatitis C infection of B lymphocytes: more tools to address pending questions.Stamataki Z. Expert review of anti-infective therapy 2010 8: 977-80

Hepatitis C virus association with peripheral blood B lymphocytes potentiates viral infection of liver-derived hepatoma cells. Stamataki Z, Shannon-Lowe C, Shaw J, Mutimer D, Rickinson AB, Gordon J, Adams DH, Balfe P, McKeating JA. Blood 2009 113:585-93

Hepatitis C virus entry and neutralization. Stamataki Z, Grove J, Balfe P, McKeating JA. Clinics in liver disease 2008 12: 693-712, x

The effect of deleting p110delta on the phenotype and function of PTEN-deficient B cells.Janas ML, Hodson D, Stamataki Z, Hill S, Welch K, Gambardella L, Trotman LC, Pandolfi PP, Vigorito E, Turner M. Journal of immunology (Baltimore, Md. : 1950) 2008 180: 739-46

Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge. Law M, Maruyama T, Lewis J, Giang E, Tarr AW, Stamataki Z, Gastaminza P, Chisari FV, Jones IM, Fox RI, Ball JK, McKeating JA, Kneteman NM, Burton DR. Nature medicine 2008 14: 25-7

Structural characterization of recombinant human CD81 produced in Pichia pastoris.Jamshad M, Rajesh S, Stamataki Z, McKeating JA, Dafforn T, Overduin M, Bill RM. Protein expression and purification 2008 57: 206-16

Hepatitis C virus cell-cell transmission in hepatoma cells in the presence of neutralizing antibodies. Timpe JM, Stamataki Z, Jennings A, Hu K, Farquhar MJ, Harris HJ, Schwarz A, Desombere I, Roels GL, Balfe P, McKeating JA. Hepatology (Baltimore, Md.) 2008 47:17-24

Hepatitis C virus envelope glycoprotein immunization of rodents elicits cross-reactive neutralizing antibodies. Stamataki Z, Coates S, Evans MJ, Wininger M, Crawford K, Dong C, Fong YL, Chien D, Abrignani S, Balfe P, Rice CM, McKeating JA, Houghton M. Vaccine 2007 25: 7773-84

Fibrinogen is localized on dark zone follicular dendritic cells in vivo and enhances the proliferation and survival of a centroblastic cell line in vitro. Lefevre EA, Hein WR, Stamataki Z, Brackenbury LS, Supple EA, Hunt LG, Monaghan P, Borhis G, Richard Y, Charleston B. Journal of leukocyte biology 2007 82: 666-77

Superinfection exclusion in cells infected with hepatitis C virus. Tscherne DM, Evans MJ, von Hahn T, Jones CT, Stamataki Z, McKeating JA, Lindenbach BD, Rice CM. Journal of virology 2007 81: 3693-703

The PI3K p110delta is required for down-regulation of RAG expression in immature B cells. Llorian M, Stamataki Z, Hill S, Turner M, Mårtensson IL. Journal of immunology (Baltimore, Md. : 1950) 2007 178: 1981-5

Scavenger receptor BI and BII expression levels modulate hepatitis C virus infectivity.Grove J, Huby T, Stamataki Z, Vanwolleghem T, Meuleman P, Farquhar M, Schwarz A, Moreau M, Owen JS, Leroux-Roels G, Balfe P, McKeating JA. Journal of virology 2007 81: 3162-9

Persistent hepatitis C virus infection in vitro: coevolution of virus and host. Zhong J, Gastaminza P, Chung J, Stamataki Z, Isogawa M, Cheng G, McKeating JA, Chisari FV. Journal of virology 2006 80: 11082-93

Attenuated liver fibrosis in the absence of B cells. Holt AP, Stamataki Z, Adams DH. Hepatology (Baltimore, Md.) 2006 43: 868-71

Identification of a cell population that produces alpha/beta interferon in vitro and in vivo in response to noncytopathic bovine viral diarrhea virus. Brackenbury LS, Carr BV, Stamataki Z, Prentice H, Lefevre EA, Howard CJ, Charleston B. Journal of virology 2005 79: 7738-44